Rotastat
Tirofiban Hydrochloride 12.5mg/50ml Injection
Rotastat is an antiplatelet medicine used in the hospital management of acute coronary syndrome. It belongs to the glycoprotein IIb/IIIa receptor inhibitor class, working by blocking platelet aggregation to reduce the risk of thrombotic cardiovascular events during and after cardiac intervention.
Product Facts
| Generic name | Tirofiban Hydrochloride |
|---|---|
| Strength & form | 12.5 mg / 50 ml — sterile solution for I.V. infusion (single-use vial) |
| Therapeutic class | Antiplatelet agent — Glycoprotein IIb/IIIa receptor inhibitor |
| Route | Intravenous use only, after dilution — hospital/cath-lab administration |
Indication
Rotastat is indicated for the treatment of Non-ST-Elevation Acute Coronary Syndrome (NSTE-ACS) — including unstable angina and non-Q-wave myocardial infarction — particularly in patients managed with an early invasive strategy (percutaneous coronary intervention), to reduce the risk of combined cardiovascular ischemic events.
Clinical Evidence
In clinical trials of tirofiban in NSTE-ACS patients (PRISM-PLUS), tirofiban in combination with heparin and aspirin was associated with:
- 32% reduction in the composite endpoint of death, myocardial infarction, or refractory ischemia
- 30% reduction in death, MI, or refractory ischemia at 7 days
- ~70% reduction in the incidence of MI at 7 days
Administration
Rotastat is administered as a controlled intravenous infusion via infusion pump, typically with a higher initial (loading) rate followed by a lower maintenance rate, in combination with heparin and aspirin, strictly under physician supervision in a hospital or catheterization lab setting. Dilute before use; do not administer by any other route.
Quality & Availability
Rotastat is manufactured under ISO-certified quality systems and distributed by Greenrays to hospital pharmacies and institutional procurement channels across Pakistan, including defense/military hospital networks.
This page is intended for healthcare professionals and institutional buyers. Rotastat is a prescription-only medicine and must be administered under qualified medical supervision. For full prescribing information, contraindications, and safety data, refer to the official product leaflet or contact Greenrays directly.